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Here, we describe the origins and evolution of these viruses, and the circumstances that led to the AIDS pandemic. Both HIVs are the result of multiple cross-species transmissions of simian immunodeficiency viruses SIVs naturally infecting African primates. Most of these transfers resulted in viruses that spread in humans to only a limited extent. Tracing the genetic changes that occurred as SIVs crossed from monkeys to apes and from apes to humans provides a new framework to examine the requirements of successful host switches and to gauge future zoonotic risk.
Acquired Immune Deficiency Syndrome AIDS was first recognized as a new disease in when increasing numbers of young homosexual men succumbed to unusual opportunistic infections and rare malignancies CDC ; Greene A retrovirus, now termed human immunodeficiency virus type 1 HIV-1 , was subsequently identified as the causative agent of what has since become one of the most devastating infectious diseases to have emerged in recent history Barre-Sinoussi et al.
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